The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a PCORI Funding Announcement (PFA) on Dec. 2, 2025, Improving Health Decision Making with Comparative Clinical Effectiveness Research in Cancer, Pain, Substance Use, Maternal Morbidity and Mortality, Intellectual and Developmental Disabilities, Sensory Health, Metabolic and Endocrine Health, Mental and Behavioral Health and Rare Diseases: Retrospective Observational Studies Leveraging Existing Data Sources.

This PCORI Funding Announcement is seeking to fund well-designed, methodologically robust retrospective observational patient-centered comparative clinical effectiveness research (CER) studies that will produce timely, impactful and patient-centered results to inform healthcare decision making and improve health outcomes. This preannouncement provides potential applicants with additional time to identify collaborators; obtain patient and stakeholder input; secure data access; and develop responsive, high-quality proposals.

Key Dates:

• PFA Opens – Dec. 2, 2025
• Applicant Town Hall – Dec. 10, 2025, 12 pm (ET)
• Letter of Intent (LOI) Deadline – Jan. 6, 2026; 5 pm (ET)
• LOI Status Notification – Feb. 3, 2026
• Application Deadline – May. 5, 2026; 5 pm (ET)

Centene has always believed the best way to deliver health care is locally. Our uniquely local approach has been our greatest strength since the beginning.

We apply that same perspective to the work of the Centene Foundation, which furthers our company’s mission by partnering with organizations with deep community expertise and history. These partnerships focus on three distinct pillars: healthcare, social services and education. Because we recognize that transforming the health of our communities requires more than one-time contributions, we seek partnerships that can grow over time and position our communities to thrive.

All our partners are charity organizations that are tax-exempt under Section 501(c)(3) or Section 170(b) of the Internal Revenue Code, and requests must meet the giving requirements and criteria for funding.

The Association of State and Territorial Health Officials (ASTHO) is seeking proposals from qualified organizations to design and implement a Rapid Response Opioid and Pain Management ECHO focused on strengthening provider capacity to manage patients affected by prescription controlled substance disruptions.

The selected partner will receive up to $140,000 to deliver two ECHO cohorts between December 2025 and July 2026, emphasizing evidence-based pain management, tapering strategies, substance use screening, and non-opioid treatment approaches.

ASTHO Point of Contact: Email Richa Ranade with any questions.

The APF Direct Action Visionary Grants seek to fund innovative interventions, based on psychological knowledge, that directly address pressing needs of communities.

Research is critical to advancing the field of psychology, but communities also need care right now. APF is uniquely positioned to accomplish both. Through APF Direct Action Visionary Grants, we are particularly interested in supporting communities and populations dealing with prejudice, bias, intolerance, and all forms of bigotry including racism, antisemitism, homophobia, and misogyny.

Projects should support APF’s four Visionary Priorities:

1. Serve Marginalized Communities
2. End Prejudice & Stigma
3. Prevent Violence
4. Explore Mind-Body Health Connections

The Robert Wood Johnson Foundation (RWJF) is taking bold leaps to transform health in our lifetime and pave the way, together, to a future where health is no longer a privilege, but a right.

We have set three ambitious goals for our work:

Economic Inclusion for Family Wellbeing
Equitable and Accountable Public Health and Healthcare Systems
Healthy and Equitable Community Conditions

Making progress toward those Generational Goals requires changing the systems that underpin our society. Currently, those systems create and uphold inequity by placing more value on some lives than others, based on race, class, and other factors. To create a more equitable future, we must identify and dismantle structural racism in our systems. We must create space for health practitioners, community leaders, and researchers to rethink the way our systems work, dream up new possibilities, and put one foot in the future to anticipate opportunities or roadblocks that future may bring.

Through our Ideas for an Equitable Future team, we support visionary thinkers—scientists, anthropologists, engineers, technologists, creatives, and others—who are imagining what the world might look like in the next 10 to 100 years.With our funding, they explore how those futures may unfold in ways that could slow down or speed up our collective efforts to dismantle structural racism and improve health equity.

By applying this future-facing lens, our grantees are uncovering how emerging social, cultural, scientific, technological, environmental, and economic trends and forces could shape the future of health for everyone. They are also discovering and experimenting with cutting-edge ideas that have the potential to tear down barriers to health and wellbeing and reinvent our systems so that they work better for us all.

The purpose of this call for proposals (CFP) is to meet the current moment by supporting timely, actionable health equity research that has been interrupted by shifts in federal funding. We will award up to $5 million for Rapid Response Research grants to help at least partially offset federal funding losses to existing research.

Rapid Response Research funding is exclusively available to applicants who have already received federal funding (e.g., from the NIH, CDC, NSF) for their health equity research, but have since had their funding partially or fully rescinded due to federal administrative actions. While we will not re-scrutinize the scientific merits of projects that have lost federal funding, our intent is to support research consistent with Evidence for Action’s mission to advance community-centered, action-oriented racial and Indigenous health equity research that focuses on structural solutions that are innovative, push beyond the status quo, and target root causes.